5-Amino-1MQ at a glance
A fast read for beginners, with evidence strength, route context, safety depth, and community activity surfaced before the deeper sections.
5-Amino-1MQ is a small membrane-permeable molecule that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme expressed in adipose tissue that consumes SAM (S-adenosylmethionine) and methyl donors to methylate nicotinamide - effectively draining both NAD+ precursors and the methyl pool. By inhibiting NNMT, 5-Amino-1MQ redirects nicotinamide back toward NAD+ synthesis and restores the methyl pool, activating SIRT1, AMPK, and other longevity-associated metabolic regulators.
In preclinical studies, 5-Amino-1MQ reduced adipocyte differentiation, activated fat-burning gene programs, and reduced body fat in diet-induced obese mice without changes in food intake. It also activated quiescent muscle stem cells (satellite cells), suggesting potential for muscle maintenance and regeneration. Unlike NAD+ precursors (NMN, NR) which simply flood the precursor pool, NNMT inhibition takes a more targeted approach by removing the drain on the system.
5-Amino-1MQ is orally bioavailable, which represents a practical advantage over most longevity peptides. It remains a research compound with no human clinical trials. Its mechanism is well-characterized at the cellular level but systemic effects in humans are not established.
Key Benefits
Saves this peptide to your Watchlist and helps you find new research, news, and questions later.