Hexarelin
Potent synthetic GH secretagogue producing stronger GH release than ipamorelin, with notable cardioprotective properties
Hexarelin is a synthetic hexapeptide and potent GH secretagogue that mimics the actions of ghrelin by binding to the GHS-R1a receptor. It is among the most potent GH-releasing peptides available, producing GH pulses significantly larger than those seen with ipamorelin or GHRP-6, though also with a less selective side-effect profile.
Unlike ipamorelin's highly selective action, hexarelin produces modest elevations in cortisol and prolactin at standard doses—an effect that limits its use for extended daily protocols but makes it valuable for acute GH pulse protocols. Its potency also means that receptor desensitization with chronic use is a consideration, often addressed through cycling.
A distinctive feature of hexarelin is its well-documented cardioprotective effect, which appears to be independent of its GH-releasing activity. Hexarelin has GHS-R1b receptors in cardiac tissue and has demonstrated protective effects against ischemia-reperfusion injury, cardiac fibrosis, and heart failure in multiple animal models. This makes it particularly interesting for individuals with cardiovascular concerns.
Primary Benefits
GHRH analog that stimulates natural growth hormone release, clinically proven to reduce visceral adipose tissue
GHRH analog with extended half-life through DAC technology, providing sustained pulsatile GH release over days
Oral GH secretagogue and ghrelin receptor agonist with non-peptide structure enabling once-daily oral dosing