Ipamorelin
Selective GH secretagogue with clean side effect profile, minimal cortisol or prolactin impact
Ipamorelin is a selective growth hormone secretagogue that stimulates the release of growth hormone from the pituitary gland. What sets ipamorelin apart from other GH-releasing peptides is its remarkable selectivity—it does not significantly affect cortisol, prolactin, or other hormones, making it one of the cleanest options in its class.
As a pentapeptide (five amino acids), ipamorelin mimics ghrelin, the "hunger hormone," but without the strong appetite-stimulating effects seen with other ghrelin mimetics. This selective action makes it popular among those seeking GH optimization without unwanted side effects.
The peptide is often used in combination with CJC-1295 (a GHRH analog) to create a synergistic effect on GH release. This combination provides both the signal to release GH (ipamorelin) and the amplification of that signal (CJC-1295).