Kisspeptin-10 at a glance
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Kisspeptin-10 is the 10-amino acid C-terminal fragment of kisspeptin-54 (metastin), a neuropeptide encoded by the KISS1 gene that was discovered as a metastasis suppressor before its critical role in reproductive neuroendocrinology was recognized. Kisspeptin neurons in the hypothalamic arcuate nucleus and anteroventral periventricular nucleus directly innervate GnRH neurons and are the primary upstream regulators of the entire hypothalamic-pituitary-gonadal (HPG) axis.
By stimulating GnRH neurons, kisspeptin-10 drives pulsatile LH release from the anterior pituitary, which in turn stimulates testosterone production in men and progesterone/estrogen in women. Unlike exogenous LH or testosterone, kisspeptin-10 works at the top of the axis - preserving the feedback mechanisms and natural hormonal rhythms. This makes it particularly interesting for fertility applications and as an alternative to clomiphene in men seeking testosterone support without suppressing the HPG axis.
Clinical trials have demonstrated kisspeptin-10's ability to restore LH pulsatility in men with hypothalamic hypogonadism, stimulate ovulation in women with fertility disorders, and serve as a diagnostic tool for HPG axis assessment. Its safety profile from clinical trials is favorable.
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