Epithalon at a glance
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Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. It is a synthetic analog of Epithalamin, a natural polypeptide extract from the pineal gland that has been studied for its lifespan-extending properties since the 1980s.
Epithalon's most studied mechanism is the activation of telomerase, the enzyme responsible for maintaining telomere length. Shortened telomeres are strongly associated with cellular senescence and aging. By activating telomerase, Epithalon may slow or partially reverse this marker of biological aging. Human studies have shown measurable telomere elongation following Epithalon cycles.
Additionally, Epithalon has demonstrated significant effects on circadian rhythm regulation, melatonin production, and neuroendocrine function - all of which decline with age and contribute to age-related disease. A body of Russian clinical research, while sometimes limited in scale, spans more than three decades and multiple patient populations.
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