KPV at a glance
A fast read for beginners, with evidence strength, route context, safety depth, and community activity surfaced before the deeper sections.
KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal fragment of alpha-melanocyte stimulating hormone (α-MSH). Alpha-MSH is known for its anti-inflammatory properties mediated through melanocortin receptors, and KPV retains this activity in a much smaller, more stable form.
KPV has been studied primarily for its effects on intestinal inflammation, where it directly reduces pro-inflammatory cytokines (TNF-α, IL-6, IL-8) in colonocytes and macrophages without the systemic effects of corticosteroids. Animal models of colitis have shown dramatic reduction in mucosal inflammation. Unlike many peptides, KPV can survive oral delivery to some extent, making gut-targeted applications particularly practical.
Research has also demonstrated KPV's effectiveness in wound healing and skin inflammation, acting locally to reduce keratinocyte and macrophage-driven inflammatory cascades. Its small size and excellent tolerability make it a promising candidate for conditions like IBD, psoriasis, and rosacea.
Key Benefits
Saves this peptide to your Watchlist and helps you find new research, news, and questions later.