KPV
Alpha-MSH derived tripeptide with potent anti-inflammatory and gut healing properties, oral or subcutaneous
KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal fragment of alpha-melanocyte stimulating hormone (α-MSH). Alpha-MSH is known for its anti-inflammatory properties mediated through melanocortin receptors, and KPV retains this activity in a much smaller, more stable form.
KPV has been studied primarily for its effects on intestinal inflammation, where it directly reduces pro-inflammatory cytokines (TNF-α, IL-6, IL-8) in colonocytes and macrophages without the systemic effects of corticosteroids. Animal models of colitis have shown dramatic reduction in mucosal inflammation. Unlike many peptides, KPV can survive oral delivery to some extent, making gut-targeted applications particularly practical.
Research has also demonstrated KPV's effectiveness in wound healing and skin inflammation, acting locally to reduce keratinocyte and macrophage-driven inflammatory cascades. Its small size and excellent tolerability make it a promising candidate for conditions like IBD, psoriasis, and rosacea.
Primary Benefits
Synthetic peptide derived from human gastric juice, known for accelerating tissue repair and reducing inflammation
Immunomodulating peptide studied across immune dysfunction, chronic infections, and oncology support — approved in 35+ countries
Human cathelicidin antimicrobial peptide — the body's primary endogenous antibiotic, with wound healing and immune defense roles