Selank
Synthetic analog of tuftsin with anxiolytic and nootropic effects, no dependency or tolerance risk
Selank is a synthetic heptapeptide analog of tuftsin, an endogenous immunomodulatory tetrapeptide. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences (the same institution behind Semax), Selank has been used clinically in Russia for generalized anxiety disorder and phobias since the early 2000s.
Unlike benzodiazepines and other conventional anxiolytics, Selank does not act on GABA receptors and carries no risk of dependence, tolerance buildup, or withdrawal. Its mechanism involves modulation of BDNF expression, stabilization of enkephalins (endogenous opioid peptides), and regulation of the serotonin and dopamine systems.
Selank is notable for combining anxiolytic and nootropic effects simultaneously—reducing anxiety while simultaneously improving cognitive clarity, memory consolidation, and focus. This dual profile makes it popular among individuals seeking calm alertness without sedation.
Primary Benefits
Synthetic ACTH analog developed in Russia, enhances BDNF production and cognitive performance
HGF/MET signaling amplifier and among the most potent synaptogenic nootropics studied — note: foundational study retracted April 2025
Cerebrolysin-inspired neurogenic peptide designed to enhance BDNF signaling and promote hippocampal neurogenesis